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Evidence that longer, tapered, pulsed-dosing is more effective than conventional regimens comes from evaluation of placebo-treated patients in a trial of a probiotic adjunct to antibiotic therapy in patients who already had one or more recurrences.
There are no controlled data to support specific tapering or pulse regimens (86). We here propose a simple cost-effective regimen: a standard 10-day course of vancomycin at a dose of 125 mg given four times daily, followed by 125 mg daily pulsed every 3 days for ten doses (Scott Curry, personal communication).